Farooqi Ammad Ahmad, Waseem Salman, Riaz Asma M, Dilawar Bilal Ahmed, Mukhtar Shahzeray, Minhaj Sehrish, Waseem Makhdoom Saad, Daniel Suneel, Malik Beenish Ali, Nawaz Ali, Bhatti Shahzad
Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, 1 km defence road, Lahore, Pakistan.
Tumour Biol. 2011 Dec;32(6):1057-70. doi: 10.1007/s13277-011-0212-3. Epub 2011 Jul 19.
PDGF is a growth factor and is extensively involved in multi-dimensional cellular dynamics. It switches on a plethora of molecules other than its classical pathway. It is engaged in various transitions of development; however, if the unleashed potentials lead astray, it brings forth tumourigenesis. Conventionally, it has been assumed that the components of this signalling pathway show fidelity and act with a high degree of autonomy. However, as illustrated by the PDGF signal transduction, reinterpretation of recent data suggests that machinery is often shared between multiple pathways, and other components crosstalk to each other through multiple mechanisms. It is important to note that metastatic cascade is an intricate process that we have only begun to understand in recent years. Many of the early steps of this PDGF cascade are not readily targetable in the clinic. In this review, we will unravel the paradoxes with reference to mitrons and cellular plasticity and discuss how disruption of signalling cascade triggers cellular proliferation phase transition and metastasis. We will also focus on the therapeutic interventions to counteract resultant molecular disorders.
血小板衍生生长因子（PDGF）是一种生长因子，广泛参与多维度的细胞动态变化。它除了激活其经典信号通路外，还能开启大量其他分子的活性。它参与了发育过程中的各种转变；然而，如果释放的潜能偏离正轨，就会引发肿瘤发生。传统上，人们认为这条信号通路的组成部分具有特异性，并且高度自主地发挥作用。然而，正如血小板衍生生长因子信号转导所表明的那样，对近期数据的重新解读表明，多种信号通路之间常常共享一些机制，而且其他组分通过多种机制相互串扰。需要注意的是，转移级联反应是一个复杂的过程，直到近年来我们才刚刚开始了解。血小板衍生生长因子级联反应的许多早期步骤在临床上难以轻易成为治疗靶点。在这篇综述中，我们将参考线粒体和细胞可塑性来揭示其中的矛盾之处，并讨论信号级联反应的破坏如何触发细胞增殖阶段转变和转移。我们还将重点关注对抗由此产生的分子紊乱的治疗干预措施。
