Miller Benjamin L
Department of Dermatology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Top Curr Chem. 2012;322:107-37. doi: 10.1007/128_2011_200.
Nucleic acids were one of the first biological targets explored with DCC, and research into the application has continued to yield novel and useful structures for sequence- and structure-selective recognition of oligonucleotides. This chapter reviews major developments in DNA- and RNA-targeted DCC, including methods under development for the conversion of DCC-derived lead compounds into probe molecules suitable for studies in vitro and in vivo. Innovative applications of DCC for the discovery of new materials based on nucleic acids and new methods for the modification of nucleic acid structure and function are also discussed.
核酸是最早用动态组合化学（DCC）探索的生物靶点之一，对其应用的研究不断产生用于寡核苷酸序列和结构选择性识别的新颖且有用的结构。本章综述了以DNA和RNA为靶点的DCC的主要进展，包括正在开发的将DCC衍生的先导化合物转化为适合体外和体内研究的探针分子的方法。还讨论了DCC在基于核酸的新材料发现以及核酸结构和功能修饰新方法方面的创新应用。
