Purtilo D T, Okano M, Grierson H L
Departments of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105.
Environ Health Perspect. 1990 Aug;88:225-30. doi: 10.1289/ehp.9088225.
Epstein-Barr virus (EBV) is a ubiquitous DNA virus that normally infects silently, establishing lifelong latency. Substantial empirical observations support the view that immunodeficiency is permissive in EBV-induced lymphoproliferative diseases (LPD). Primary immune deficient patients such as those with X-linked lymphoproliferative disease and individuals with acquired immune deficiency secondary to immunosuppressive drugs for organ transplantation or individuals infected with human immunodeficiency virus are also at very high risk for lethal LPD. The importance of immunodeficiency and EBV in the development of head and neck carcinomas and uterine cervical carcinoma is less clear. Methods are available for detecting immunodeficiency and EBV genome and thus preventive strategies are being developed to preclude LPD from occurring.
爱泼斯坦-巴尔病毒（EBV）是一种普遍存在的DNA病毒，通常进行无症状感染，并建立终身潜伏感染。大量实证观察结果支持以下观点：免疫缺陷会引发EBV诱导的淋巴增殖性疾病（LPD）。原发性免疫缺陷患者，如患有X连锁淋巴增殖性疾病的患者、因器官移植使用免疫抑制药物继发获得性免疫缺陷的个体，或感染人类免疫缺陷病毒的个体，发生致命性LPD的风险也非常高。免疫缺陷和EBV在头颈癌和子宫颈癌发生过程中的重要性尚不清楚。现有检测免疫缺陷和EBV基因组的方法，因此正在制定预防策略以防止LPD的发生。
