Department of Cardiology, Tianjin Institute of Cardiology, 2nd Hospital of Tianjin Medical University, Tianjin, People’s Republic of China.
Cardiol J. 2011;18(4):364-70.
The relationship between autoantibodies against human oxidized low-density lipoprotein (anti-oxLDL) and the progression of atherosclerotic diseases is unclear. This study aimed to investigate the association between serum anti-oxLDL titers and the severity and extent of coronary stenotic lesions.
We measured the titers of IgG anti-oxLDL by enzyme-linked immunosorbent assay (ELISA) in 154 consecutive patients undergoing coronary angiography for suspected coronary heart disease (CHD). The severity and extent of coronary stenotic lesions were evaluated on coronary angiography findings by Gensini score.
The anti-oxLDL titers were significantly lower in 117 patients with CHD than those in 37 controls (p<0.01). The serum anti-oxLDL titers were significantly correlated to serum levels of globulin (r = 0.405), conjugated bilirubin (r = 0.280), high-density lipoprotein (HDL) cholesterol (r = 0.238), homeostatic model assessment for insulin resistance (HOMA-IR) (r = -0.267), high sensitivity C-reactive protein (hs-CRP) (r = -0.230), triglyceride (r = -0.207), advanced glycation end products (AGEs) (r = -0.200), and malondialdehyde (r = -0.165). However, only HDL cholesterol and AGEs remained independent predictors of the anti-oxLDL titers after adjusting for confounders. Multivariate regression analysis showed that the anti-oxLDL titers, as well as serum levels of hs-CRP, fasting glucose, and albumin, were significantly associated with Gensini scores.
Titers of anti-oxLDL are inversely associated with complicated proatherogenic metabolic risk factors, and the severity of coronary stenotic lesions calculated by Gensini scores, supporting a protective role for anti-oxLDL against the progression of atherosclerosis.
自身抗体针对人氧化型低密度脂蛋白（抗 oxLDL）与动脉粥样硬化性疾病进展之间的关系尚不清楚。本研究旨在探讨血清抗 oxLDL 滴度与冠状动脉狭窄病变严重程度和范围的关系。
我们通过酶联免疫吸附试验（ELISA）测量了 154 例疑似冠心病（CHD）行冠状动脉造影的连续患者的 IgG 抗 oxLDL 滴度。通过 Gensini 评分评估冠状动脉造影结果来评估冠状动脉狭窄病变的严重程度和范围。
117 例 CHD 患者的抗 oxLDL 滴度明显低于 37 例对照组（p<0.01）。血清抗 oxLDL 滴度与球蛋白（r = 0.405）、结合胆红素（r = 0.280）、高密度脂蛋白（HDL）胆固醇（r = 0.238）、胰岛素抵抗稳态模型评估（HOMA-IR）（r = -0.267）、高敏 C 反应蛋白（hs-CRP）（r = -0.230）、甘油三酯（r = -0.207）、晚期糖基化终产物（AGEs）（r = -0.200）和丙二醛（r = -0.165）呈显著相关。然而，仅在调整混杂因素后，HDL 胆固醇和 AGEs 仍然是抗 oxLDL 滴度的独立预测因子。多元回归分析显示，抗 oxLDL 滴度以及 hs-CRP、空腹血糖和白蛋白的血清水平与 Gensini 评分显著相关。
抗 oxLDL 滴度与复杂的促动脉粥样硬化代谢危险因素呈负相关，并且 Gensini 评分计算的冠状动脉狭窄病变严重程度与抗 oxLDL 相关，这表明抗 oxLDL 对动脉粥样硬化的进展具有保护作用。
