甲基黄嘌呤诱导的准吗啡戒断行为机制。

Mechanism of quasi-morphine withdrawal behaviour induced by methylxanthines.

作者信息

Butt N M, Collier H O, Cuthbert N J, Francis D L, Saeed S A

出版信息

Eur J Pharmacol. 1979 Feb 1;53(4):375-8. doi: 10.1016/0014-2999(79)90462-x.

Abstract

Of 7 phosphodiesterase inhibitors tested for ability to induce a quasi-morphine withdrawal syndrome (QMWS) in opiate-naive rats, five were effective in a dose-related way. These, in descending order of potency, were IBMX, ICI-63197, RO-201724, theophylline and caffeine. Their potencies in inducing a QMWS correlated significantly (P less than 0.05) with those in inhibiting low Km cyclic AMP phosphodiesterase of rat brain homogenate. There was no correlation with potencies in inhibiting cyclic GMP phosphodiesterase.

摘要

在对7种磷酸二酯酶抑制剂进行测试，以观察其在未使用过阿片类药物的大鼠中诱导准吗啡戒断综合征（QMWS）的能力时，有5种呈现出剂量相关的有效性。这些药物按效力从高到低依次为异丁基甲基黄嘌呤（IBMX）、ICI - 63197、RO - 201724、茶碱和咖啡因。它们诱导QMWS的效力与抑制大鼠脑匀浆低Km环磷酸腺苷磷酸二酯酶的效力显著相关（P小于0.05）。与抑制环磷酸鸟苷磷酸二酯酶的效力无关。