• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Methylxanthine inhibitors of phosphodiesterases.

作者信息

Wells J N, Miller J R

出版信息

Methods Enzymol. 1988;159:489-96. doi: 10.1016/0076-6879(88)59048-1.

DOI:10.1016/0076-6879(88)59048-1
PMID:2457788
Abstract
摘要

相似文献

1
Methylxanthine inhibitors of phosphodiesterases.磷酸二酯酶的甲基黄嘌呤抑制剂。
Methods Enzymol. 1988;159:489-96. doi: 10.1016/0076-6879(88)59048-1.
2
Phosphodiesterase inhibitors as tools in cyclic nucleotide research: a precautionary comment.磷酸二酯酶抑制剂作为环核苷酸研究工具：一则预防性评论。
Mol Cell Endocrinol. 1981 Jul;23(1):1-9. doi: 10.1016/0303-7207(81)90112-x.
3
Dihydro- and tetrahydroisoquinolines as inhibitors of cyclic nucleotide phosphodiesterases from dog heart. Structure-activity relationships.二氢和四氢异喹啉作为犬心环核苷酸磷酸二酯酶的抑制剂。构效关系。
Biochem Pharmacol. 1979 Apr 15;28(8):1307-12. doi: 10.1016/0006-2952(79)90430-1.
4
Inhibition of human lung cyclic GMP and cyclic AMP phosphodiesterases by certain nucleosides, nucleotides, and pharmacological phosphodiesterase inhibitors.某些核苷、核苷酸及药理学磷酸二酯酶抑制剂对人肺环鸟苷酸和环腺苷酸磷酸二酯酶的抑制作用。
Biochem Pharmacol. 1979 Apr 1;28(7):1107-12. doi: 10.1016/0006-2952(79)90313-7.
5
Analysis of the relationship between pharmacological inhibition of cyclic nucleotide phosphodiesterase and relaxation of canine tracheal smooth muscle.环核苷酸磷酸二酯酶的药理学抑制与犬气管平滑肌舒张之间关系的分析
Biochem Pharmacol. 1979 Apr 15;28(8):1391-5. doi: 10.1016/0006-2952(79)90442-8.
6
Selective phosphodiesterase inhibition and alterations of cardiac function by alkylated xanthines.
Mol Pharmacol. 1981 Jul;20(1):179-89.
7
Cyclic nucleotide phosphodiesterase activities of the embryonic chick ovary.胚胎期鸡卵巢的环核苷酸磷酸二酯酶活性
Gen Comp Endocrinol. 1981 Aug;44(4):409-17. doi: 10.1016/0016-6480(81)90327-0.
8
Resolution of soluble cyclic nucleotide phosphodiesterase isoenzymes, from liver and hepatocytes, identifies a novel IBMX-insensitive form.从肝脏和肝细胞中分离出可溶性环核苷酸磷酸二酯酶同工酶，鉴定出一种新型的对异丁基甲基黄嘌呤（IBMX）不敏感的形式。
Biochem Pharmacol. 1989 Nov 15;38(22):4123-36. doi: 10.1016/0006-2952(89)90694-1.
9
Selective inhibition of cyclic nucleotide phosphodiesterases by analogues of 1-methyl-3-isobutylxanthine.
Biochemistry. 1977 Jul 26;16(15):3316-21. doi: 10.1021/bi00634a006.
10
Measurements of cyclic AMP and cyclic GMP phosphodiesterase activity in isolated tubular segments.
Kidney Int. 1980 Oct;18(4):512-8. doi: 10.1038/ki.1980.166.

引用本文的文献

1
The associations between caffeine treatment and common preterm morbidities: a retrospective cohort analysis.咖啡因治疗与常见早产并发症之间的关联：一项回顾性队列分析。
Front Pediatr. 2023 Jul 10;11:1178976. doi: 10.3389/fped.2023.1178976. eCollection 2023.
2
Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand.钙和碳酸氢盐信号通路在匹配 ATP 产生与需求方面具有关键的、共鸣的作用。
Elife. 2023 Jun 5;12:e84204. doi: 10.7554/eLife.84204.
3
Pleiotropic Effects of Caffeine Leading to Chromosome Instability and Cytotoxicity in Eukaryotic Microorganisms.
咖啡因的多效性作用导致真核微生物的染色体不稳定性和细胞毒性。
J Microbiol Biotechnol. 2021 Feb 28;31(2):171-180. doi: 10.4014/jmb.2011.11042.
4
Homogeneous single-label cGMP detection platform for the functional study of nitric oxide-sensitive (soluble) guanylyl cyclases and cGMP-specific phosphodiesterases.用于研究一氧化氮敏感（可溶性）鸟苷酸环化酶和 cGMP 特异性磷酸二酯酶功能的均相单标记 cGMP 检测平台。
Sci Rep. 2020 Oct 15;10(1):17469. doi: 10.1038/s41598-020-74611-x.
5
Xanthine scaffold: scope and potential in drug development.黄嘌呤骨架：药物研发中的范围与潜力
Heliyon. 2018 Oct 3;4(10):e00829. doi: 10.1016/j.heliyon.2018.e00829. eCollection 2018 Oct.
6
Overcoming chemoresistance in pancreatic cancer cells: role of the bitter taste receptor T2R10.克服胰腺癌细胞中的化疗耐药性：苦味受体T2R10的作用
J Cancer. 2018 Feb 1;9(4):711-725. doi: 10.7150/jca.21803. eCollection 2018.
7
Caffeine Positively Modulates Ferritin Heavy Chain Expression in H460 Cells: Effects on Cell Proliferation.咖啡因正向调节H460细胞中铁蛋白重链的表达：对细胞增殖的影响。
PLoS One. 2016 Sep 22;11(9):e0163078. doi: 10.1371/journal.pone.0163078. eCollection 2016.
8
Maternal caffeine administration leads to adverse effects on adult mice offspring.母体咖啡因摄入会导致成年小鼠后代出现不良反应。
Eur J Nutr. 2013 Dec;52(8):1891-900. doi: 10.1007/s00394-012-0490-6. Epub 2013 Jan 5.
9
β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells.β-肾上腺素能 cAMP 信号主要受培养的成年大鼠主动脉平滑肌细胞中磷酸二酯酶 4 的调节。
PLoS One. 2012;7(10):e47826. doi: 10.1371/journal.pone.0047826. Epub 2012 Oct 18.
10
Multiple Ca2+-dependent mechanisms regulate L-type Ca2+ current in retinal amacrine cells.多种依赖 Ca2+ 的机制调节视网膜无长突细胞中的 L 型 Ca2+ 电流。
J Neurophysiol. 2010 Oct;104(4):1849-66. doi: 10.1152/jn.00031.2010. Epub 2010 Aug 4.