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Phosphodiesterase inhibitors as tools in cyclic nucleotide research: a precautionary comment.

作者信息

Wells J N, Kramer G L

出版信息

Mol Cell Endocrinol. 1981 Jul;23(1):1-9. doi: 10.1016/0303-7207(81)90112-x.

DOI:10.1016/0303-7207(81)90112-x
PMID:6167475
Abstract
摘要

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Cyclic AMP-specific phosphodiesterase inhibitor rolipram and RO-20-1724 promoted apoptosis in HL60 promyelocytic leukemic cells via cyclic AMP-independent mechanism.环磷酸腺苷特异性磷酸二酯酶抑制剂咯利普兰和RO-20-1724通过不依赖环磷酸腺苷的机制促进HL60早幼粒细胞白血病细胞凋亡。
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