Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
J Magn Reson Imaging. 2011 Oct;34(4):764-73. doi: 10.1002/jmri.22662. Epub 2011 Jul 18.
To identify the neural correlates of cognitive improvement in mild Alzheimer's disease (AD) subjects following 12 weeks of donepezil treatment.
Resting-state functional connectivity magnetic resonance imaging (R-fMRI) was used to measure the hippocampal functional connectivity (HFC) in 14 mild AD and 18 age-matched normal (CN) subjects. AD subjects were scanned at baseline and after donepezil treatment. CN subjects were scanned only at baseline as a reference to identify regions correlated or anticorrelated to the hippocampus. Before each scan, participants underwent cognitive, behavioral, and functional assessments.
After donepezil treatment, neural correlates of cognitive improvement measured by Mini-Mental State Examination scores were identified in the left parahippocampus, dorsolateral prefrontal cortex (DLPFC), and inferior frontal gyrus. Improvement in AD Assessment Scale-cognitive subscale scores correlated with the HFC changes in the left DLPFC and middle frontal gyrus. Stronger recovery in the network connectivity was associated with cognitive improvement.
R-fMRI may provide novel insights into the brain's responses to AD treatment in clinical pharmacological trials, and also may predict clinical response.
确定多奈哌齐治疗 12 周后轻度阿尔茨海默病（AD）患者认知改善的神经相关性。
使用静息态功能磁共振成像（R-fMRI）测量 14 名轻度 AD 和 18 名年龄匹配的正常对照（CN）受试者的海马功能连接（HFC）。AD 受试者在基线和多奈哌齐治疗后进行扫描。CN 受试者仅在基线时进行扫描，作为识别与海马相关或相反的区域的参考。在每次扫描之前，参与者接受认知、行为和功能评估。
多奈哌齐治疗后，通过 Mini-Mental State Examination 评分测量的认知改善的神经相关性在左侧海马旁回、背外侧前额叶皮质（DLPFC）和下额回中被识别。AD 评估量表认知分量表评分的改善与左侧 DLPFC 和中额回的 HFC 变化相关。网络连接的更强恢复与认知改善相关。
R-fMRI 可能为临床药物试验中大脑对 AD 治疗的反应提供新的见解，并可能预测临床反应。
