来自印度北部的 2 型糖尿病患者的口盲传输时间和小肠细菌过度生长。
Orocecal transit time and small intestinal bacterial overgrowth in type 2 diabetes patients from North India.
机构信息
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
Diabetes Technol Ther. 2011 Nov;13(11):1115-20. doi: 10.1089/dia.2011.0078. Epub 2011 Jul 19.
BACKGROUND
Diarrhea, constipation, flatulence, and abdominal pain are common complaints in type 2 diabetes patients. Impaired intestinal motility is often followed by small intestinal bacterial overgrowth (SIBO). Therefore, this study was planned to determine the incidence of SIBO and its relation with orocecal transit time (OCTT) in type 2 diabetes patients.
SUBJECTS AND METHODS
SIBO and OCTT were measured by using noninvasive glucose and lactulose hydrogen breath tests, respectively. For this study, 84 patients with type 2 diabetes mellitus in the age range 30-65 years and 45 age-matched apparently healthy controls were enrolled.
RESULTS
The glucose hydrogen breath test was suggestive of SIBO in 15.5% of patients with type 2 diabetes mellitus but in one (2.2%) of controls. There was a significant increase (P<0.001) in OCTT in type 2 diabetes patients compared with controls. It was also observed that OCTT in type 2 diabetes patients with SIBO was significantly delayed (P<0.001) compared with type 2 diabetes patients without SIBO.
CONCLUSION
This study indicates that SIBO in diabetes patients may be due to delayed OCTT.
背景
腹泻、便秘、腹胀和腹痛是 2 型糖尿病患者常见的主诉。肠动力障碍常伴有小肠细菌过度生长（SIBO）。因此，本研究旨在确定 2 型糖尿病患者 SIBO 的发生率及其与口盲传输时间（OCTT）的关系。
受试者和方法
分别采用无创葡萄糖和乳果糖氢呼气试验来测量 SIBO 和 OCTT。本研究纳入了 84 例年龄在 30-65 岁的 2 型糖尿病患者和 45 名年龄匹配的健康对照者。
结果
葡萄糖氢呼气试验提示 15.5%的 2 型糖尿病患者存在 SIBO，但对照组中仅 1 例（2.2%）存在。与对照组相比，2 型糖尿病患者的 OCTT 显著增加（P<0.001）。此外，还观察到 2 型糖尿病合并 SIBO 患者的 OCTT 明显延迟（P<0.001）。
结论
本研究表明，糖尿病患者的 SIBO 可能是由于 OCTT 延迟所致。
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