Section of Gastroenterology, Department of Emergency and Organ Transplantation, University "Aldo Moro" of Bari, 70124 Bari, Italy.
PhD Course in Organs and Tissues Transplantation and Cellular Therapies, Department of Emergency and Organ Transplantation, University "Aldo Moro" of Bari, 70124 Bari, Italy.
Int J Mol Sci. 2020 May 16;21(10):3531. doi: 10.3390/ijms21103531.
Small intestinal bacterial overgrowth (SIBO) is a condition hallmarked by an increase in the concentration of colonic-type bacteria in the small bowel. Watery diarrhea, bloating, abdominal pain and distension are the most common clinical manifestations. Additionally, malnutrition and vitamin (B12, D, A, and E) as well as minerals (iron and calcium) deficiency may be present. SIBO may mask or worsen the history of some diseases (celiac disease, irritable bowel disease), may be more common in some extra-intestinal disorders (scleroderma, obesity), or could even represent a pathogenetic link with some diseases, in which a perturbation of intestinal microbiota may be involved. On these bases, we performed a review to explore the multiple links between SIBO and digestive and extra-intestinal diseases.
小肠细菌过度生长（SIBO）是一种以小肠内结肠型细菌浓度增加为特征的疾病。水样腹泻、腹胀、腹痛和腹胀是最常见的临床表现。此外，还可能存在营养不良以及维生素（B12、D、A 和 E）和矿物质（铁和钙）缺乏。SIBO 可能会掩盖或加重某些疾病（乳糜泻、肠易激综合征）的病史，在某些肠外疾病（硬皮病、肥胖症）中更为常见，甚至可能与某些疾病存在发病机制联系，其中肠道微生物群的紊乱可能涉及其中。基于这些原因，我们进行了一项综述，以探讨 SIBO 与消化道和肠外疾病之间的多种联系。
