Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Ocul Immunol Inflamm. 2011 Aug;19(4):286-92. doi: 10.3109/09273948.2011.580072.
To compare the frequencies of attacks before and after immunomodulatory therapy (IMT) with mycophenolate mofetil (MMF) in recurrent punctate inner choroidopathy (PIC) and to report fundus autofluorescence (FAF) findings.
Eight patients who had at least two recurrent episodes of increased activity before MMF and 12 months of documented clinical course before and after MMF were included. The frequencies of attacks before and after MMF were compared. FAF images evaluated.
Before MMF, the 8 patients experienced 19 attacks of recurrent disease activity; during MMF therapy, 3 (38%) patients experienced 6 recurrent episodes. The attack frequencies were 1.09 ± 0.75 before and 0.23 ± 0.32 during treatment (p = .036). Among the 6 patients who had FAF, surrounding hyperautofluorescent halo was detected in 4 and recurrence occurred in 2 who did not show any changes on the intensity during treatment.
In the index study, the employment of MMF has decreased frequency of attacks in recurrent PIC. FAF may be employed to monitor and predict the response to treatment.
比较霉酚酸酯（MMF）免疫调节治疗前后复发性点状内层脉络膜炎（PIC）的发作频率，并报告眼底自发荧光（FAF）的结果。
纳入了 8 名患者，他们在 MMF 之前至少有两次复发活动，并且在 MMF 之前和之后有 12 个月的记录临床病程。比较了 MMF 前后的发作频率。评估 FAF 图像。
在 MMF 之前，8 名患者经历了 19 次复发性疾病活动发作；在 MMF 治疗期间，3 名（38%）患者经历了 6 次复发。发作频率分别为治疗前 1.09±0.75 次和治疗期间 0.23±0.32 次（p=0.036）。在进行 FAF 的 6 名患者中，4 名患者检测到周围高自发荧光晕，2 名在治疗期间强度没有任何变化的患者出现复发。
在本研究中，MMF 的应用降低了复发性 PIC 的发作频率。FAF 可用于监测和预测治疗反应。
