仙台病毒诱导培养的人滋养层细胞和绒毛膜癌细胞系产生干扰素。
Interferon production by cultured human trophoblasts and choriocarcinoma cell lines induced by Sendai virus.
作者信息
Tóth F D, Nørskov-Lauritsen N, Juhl C B, Aboagye-Mathiesen G, Ebbesen P
机构信息
Department of Virus and Cancer, Danish Cancer Society, Aarhus, Denmark.
出版信息
J Gen Virol. 1990 Dec;71 ( Pt 12):3067-9. doi: 10.1099/0022-1317-71-12-3067.
Human term-placental trophoblasts in primary culture were studied for an interferon (IFN) response when challenged with Sendai virus and compared to three choriocarcinoma cell lines, placental fibroblasts and placental macrophages. Normal trophoblasts were high producers and released both IFN-alpha and IFN-beta. In contrast, one choriocarcinoma cell line was a low producer and all malignant lines produced only IFN-beta. Circulating monocytes produce IFN-alpha but placental macrophages secreted IFN-beta and some IFN-alpha, suggesting that IFN production may be dependent on the stage of differentiation. A role for trophoblast IFNs in protection of the foetus against virus infections is proposed.
对原代培养的人足月胎盘滋养层细胞在用仙台病毒攻击时的干扰素（IFN）反应进行了研究，并与三种绒毛膜癌细胞系、胎盘成纤维细胞和胎盘巨噬细胞进行了比较。正常滋养层细胞是高效生产者，可释放α干扰素和β干扰素。相比之下，一种绒毛膜癌细胞系是低效生产者，所有恶性细胞系仅产生β干扰素。循环单核细胞产生α干扰素，但胎盘巨噬细胞分泌β干扰素和一些α干扰素，这表明干扰素的产生可能取决于分化阶段。有人提出滋养层干扰素在保护胎儿免受病毒感染方面发挥作用。
Zotero 插件