Department of Dermatology, Hanyang University Guri Hospital, Guri, Gyeonggi-do, Korea.
Clin Exp Dermatol. 2011 Aug;36(6):624-7. doi: 10.1111/j.1365-2230.2010.04008.x.
Bisphosphonates are potent inhibitors of osteoclastic bone resorption, and have been used for decades to control medical conditions associated with an increase in bone resorption, such as bone metastases and osteoporosis. Osteonecrosis of the jaw (ONJ) is a devastating side-effect of bisphosphonate therapy, which presents as exposed bone, accompanied by pain, swelling and purulent secretions. Although predominantly recognized by oral and maxillofacial surgeons because of the bony and intraoral features of the disease, ONJ may also present on the skin as a cutaneous sinus tract. We present the case of a 67-year-old woman who presented with ONJ after oral bisphosphonate treatment for osteoporosis.
双膦酸盐是强效的破骨细胞骨吸收抑制剂，已被使用数十年以控制与骨吸收增加相关的医疗状况，例如骨转移和骨质疏松症。颌骨坏死（ONJ）是双膦酸盐治疗的一种破坏性副作用，表现为暴露的骨骼，伴有疼痛、肿胀和脓性分泌物。尽管由于疾病的骨骼和口腔内特征，主要被口腔颌面外科医生识别，但 ONJ 也可能在皮肤上表现为皮肤窦道。我们报告了一例 67 岁女性病例，该患者在接受骨质疏松症的口服双膦酸盐治疗后出现 ONJ。
