Department of Dermatology, University of California-San Francisco, San Francisco, California, USA.
J Am Acad Dermatol. 2010 Apr;62(4):672-6. doi: 10.1016/j.jaad.2008.09.021. Epub 2010 Feb 11.
Bisphosphonates are endogenous pyrophosphate analogs that work to inhibit osteoclast activity. They are commonly used in the treatment of patients with bone related diseases, such as solid tumor metastasis and osteoporosis. One of the infrequent but not rare side effects, especially with high doses of bisphosphonates, is osteonecrosis of the jaw. Although predominantly recognized by dentists because of the bony and intraoral manifestations of the disease, it may also present on the skin. We present a case of osteonecrosis of the jaw resembling two flesh-colored papules associated with dental sinus tracts to highlight the clinical manifestations that dermatologists may encounter, and review the literature on this rare but morbid condition.
双膦酸盐是内源性焦磷酸盐类似物，可抑制破骨细胞活性。它们常用于治疗与骨骼相关的疾病患者，如实体瘤转移和骨质疏松症。其中一种罕见但并不罕见的副作用，特别是在大剂量使用双膦酸盐时，是颌骨坏死。尽管由于疾病的骨和口腔内表现，主要被牙医识别，但它也可能出现在皮肤上。我们提出了一个类似于两个肉色丘疹的颌骨坏死病例，伴有牙窦道，以强调皮肤科医生可能遇到的临床表现，并回顾了这种罕见但病态的情况的文献。
