影响局部晚期直肠癌高剂量放化疗后肿瘤退缩分级可重复性的因素。
Factors influencing reproducibility of tumour regression grading after high-dose chemoradiation of locally advanced rectal cancer.
机构信息
Department of Clinical Pathology, Vejle Hospital, Kabbeltoft, 7100 Vejle, Denmark.
出版信息
Histopathology. 2011 Jul;59(1):18-21. doi: 10.1111/j.1365-2559.2011.03888.x.
AIMS
High-dose chemoradiation is now considered the standard treatment of locally advanced rectal cancer. To provide feedback on the effect of this treatment, several regression grading systems have been proposed. For a grading system to be useful it has to be reproducible. The aim of this study was to test the reproducibility of a five-point grading system, proposed originally by Mandard, and to describe the sources of disagreement.
METHODS AND RESULTS
Tumour regression was assessed independently by two observers on 100 consecutive chemoradiated rectal cancer specimens. The grading system was extremely reproducible, with weighted and unweighted kappa values of 0.89 and 0.82, respectively. The most frequent source of disagreement was assessment of the relative amount of fibrosis. Displacement of epithelium was a minor source of disagreement.
CONCLUSIONS
The five-point grading system of Mandard is extremely reproducible.
目的
高剂量放化疗目前被认为是局部晚期直肠癌的标准治疗方法。为了提供对这种治疗效果的反馈，已经提出了几种回归分级系统。为了使分级系统有用，它必须具有可重复性。本研究的目的是测试 Mandard 最初提出的五分制分级系统的可重复性，并描述意见分歧的来源。
方法和结果
两名观察者独立评估了 100 例连续接受放化疗的直肠癌标本的肿瘤消退情况。该分级系统具有极好的可重复性，加权和非加权kappa 值分别为 0.89 和 0.82。最常见的意见分歧来源是纤维化的相对程度评估。上皮移位是一个较小的意见分歧来源。
结论
Mandard 的五分制分级系统具有极好的可重复性。
Zotero 插件