Laboratory for Experimental Surgery and Surgical Research, N. S. Christeas Medical School, University of Athens, Athens, Greece.
Fundam Clin Pharmacol. 2012 Feb;26(1):72-85. doi: 10.1111/j.1472-8206.2011.00967.x. Epub 2011 Jul 20.
Remifentanil belongs to opioid drugs, and its pharmacokinetic characteristics make it unique in this class of drugs and appropriate for use during intubation without neuromuscular blockage. This up-to-date review aims to summarize the findings of recent studies regarding remifentanil and intubation. Remifentanil combined either with propofol or with inhaled anesthetic agents has been proved to provide acceptable intubating conditions. Regarding children patients, remifentanil can be used safely, and as far as intubating conditions are concerned, its effectiveness is as excellent as with neuromuscular blockage. Strong evidence exists that illuminates the usefulness of the drug in cases of difficult airway as well as in neuromuscular diseases. Beyond all these favorable characteristics, anesthesiologists must be conscious with the use of remifentanil.
瑞芬太尼属于阿片类药物，其药代动力学特点使它在该类药物中独具特色，适合在无神经肌肉阻滞的情况下进行插管。这篇最新综述旨在总结有关瑞芬太尼和插管的近期研究结果。瑞芬太尼与丙泊酚或吸入麻醉剂联合使用已被证明可提供可接受的插管条件。对于儿童患者，瑞芬太尼可以安全使用，就插管条件而言，其效果与神经肌肉阻滞一样出色。有强有力的证据表明，该药在困难气道和神经肌肉疾病中具有一定的应用价值。除了所有这些有利的特点外，麻醉师必须意识到瑞芬太尼的使用。
