Melegari M, Scaglioni P P, Mao G P, Pasquinelli C, Baldini G
Cattedra di Gastroenterologia, Università di Modena.
Medicina (Firenze). 1990 Apr-Jun;10(2):154-7.
Human hepatic estrogen receptors (ER) were investigated in 17 healthy subjects (13 males and 4 females) and 70 patients with chronic liver disease (45 males and 25 females). Characterization of the estrogen binders in cytosol from human male liver showed two classes of binders, the first of them corresponding to estrogen receptor (Kd = 10(-10) M), and the second representing a low affinity binder (KD = 10(-8) M). Increased ER levels were found in males with chronic liver disease, patients with primary hepatic carcinoma (PHC) having about twice the levels of normal males. Normal females had basal values about three times higher than control males; during the progression of chronic liver disease, ER levels fell to arise again slowly so that, in PHC, values were about half of those in normal females. Prolonged alcohol abuse appeared to induce a marked increase in ER levels both in male and in female patients. The increase was maximal in patients who were still actively drinking and in those with histological signs of acute alcoholic hepatitis.
对17名健康受试者（13名男性和4名女性）以及70名慢性肝病患者（45名男性和25名女性）的人类肝脏雌激素受体（ER）进行了研究。对人类男性肝脏胞质溶胶中雌激素结合物的特性分析显示有两类结合物，其中第一类对应雌激素受体（解离常数Kd = 10⁻¹⁰ M），第二类代表低亲和力结合物（KD = 10⁻⁸ M）。发现慢性肝病男性患者的ER水平升高，原发性肝癌（PHC）患者的ER水平约为正常男性的两倍。正常女性的基础值约为对照男性的三倍；在慢性肝病进展过程中，ER水平下降后又缓慢上升，因此在PHC患者中，其值约为正常女性的一半。长期酗酒似乎会导致男性和女性患者的ER水平显著升高。这种升高在仍在积极饮酒的患者以及有急性酒精性肝炎组织学迹象的患者中最为明显。
