Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka.
Asian Pac J Trop Med. 2011 Jan;4(1):13-5. doi: 10.1016/S1995-7645(11)60023-0. Epub 2011 Jan 15.
To investigated the antisecrectory activities of the methanol extract, chloroform fraction and methanol fraction of Picralima nitida seeds.
The methanol extract of Picralima nitida seeds was fractionated into chloroform fraction and methanol fraction. They were evaluated for antiulcer activity and gastric emptying time in rats using aspirin-pylorus-ligation model.
Oral administration of the methanol extract, chloroform fraction and methanol fraction at 1 000 mg/kg reduced gastric ulcer by 56.4%, 40.0% and 56.3%, respectively; and the fractions of the extract significantly (P<0.05) reduced gastric emptying time when compared to the control. Gastric acidity was significantly decreased when compared with saline group, 40.25 mEq/L in methanol extract, 50.0 mEq/L in chloroform fraction 51.25 mEq/L in methanol fraction but had no significant effect on the gastric secretion volume.
These findings showed that methanol extract, chloroform fraction and methanol fraction of the seeds of Picralima possessed potent antiulcer properties and some antisecretory properties.
研究地构叶种子甲醇提取物、氯仿部位和甲醇部位的抗分泌活性。
地构叶种子甲醇提取物被分为氯仿部位和甲醇部位。采用阿司匹林-幽门结扎模型，评估它们在大鼠中的抗溃疡活性和胃排空时间。
甲醇提取物、氯仿部位和甲醇部位在 1000mg/kg 剂量下口服给药，分别使胃溃疡减少 56.4%、40.0%和 56.3%；与对照组相比，各提取物的各部位均显著（P<0.05）降低了胃排空时间。与生理盐水组相比，甲醇提取物组的胃酸显著降低（40.25 mEq/L），氯仿部位组为 50.0 mEq/L，甲醇部位组为 51.25 mEq/L，但对胃分泌量没有显著影响。
这些发现表明，地构叶种子的甲醇提取物、氯仿部位和甲醇部位具有较强的抗溃疡特性和一些抗分泌特性。
