Pharmaceutical Fund and Supply Agency, Bahir Dar, Ethiopia.
Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Biomed Res Int. 2021 Apr 9;2021:6685395. doi: 10.1155/2021/6685395. eCollection 2021.
The stem bark of is used by Ethiopian traditional healers and the community for the treatment of peptic ulcer disease. Thus, the current study was aimed at evaluating the antiulcer effect of hydro-methanol extract and solvent fractions of .
The stem bark of was collected and shed dried. Then, the stem bark was extracted by 80% hydro-methanol solvents and dried. The part of the dried hydro-methanol extract was further fractionated with n-hexane, chloroform, and distilled water. Dose-dependent pylorus ligation, curative indomethacin-induced, and time-dependent ethanol-induced ulcer models were evaluated for the hydro-methanol extract and solvent fractions. Statistical analysis was done by using the Statistical Package for the Social Sciences (SPSS) version 24. The analyses were carried out using one-way analysis of variance (ANOVA), followed by Tukey's multiple comparison tests. The result was considered significant when < 0.05.
The extract of showed a significant ( < 0.001) reduction in total acidity at all the tested doses (100, 200, and 400 mg/kg). All the tested doses of the hydro-methanol extract significantly reduced the gastric volume as compared to the vehicle (NC) ( < 0.01). The gastric pH was significantly ( < 0.05) increased by 200 and 400 mg/kg. Similarly, 200 mg/kg and 400 mg/kg significantly ( < 0.05) lowered gastric ulceration as compared to the NC. The hydro-methanol extract and aqueous fractions of at 200 mg/kg showed significant ( < 0.05) reduction in the ulcer index on a repeated dose of the hydro-methanol and solvent fractions. Ulcer healing effect on indomethacin-induced ulcer was not significant ( > 0.05) for all tested doses of the hydro-methanol extract.
The study demonstrated that the stem bark of has a potential antiulcer activity that might be due to antisecretory or cytoprotective effects.
在埃塞俄比亚传统医学中，白皮樟的茎皮被用于治疗消化性溃疡疾病，社区也用其治疗消化性溃疡疾病。因此，本研究旨在评估白皮樟的水-甲醇提取物和溶剂级分的抗溃疡作用。
采集白皮樟的茎皮并晾干，然后用 80%的水-甲醇溶剂提取，干燥后，将部分干燥的水-甲醇提取物用正己烷、氯仿和蒸馏水进一步分级。采用水-甲醇提取物和溶剂级分进行剂量依赖性幽门结扎、吲哚美辛诱导的治疗性和乙醇诱导的时间依赖性溃疡模型评估。使用社会科学统计软件包（SPSS）版本 24 进行统计分析。采用单因素方差分析（ANOVA），然后进行 Tukey 多重比较检验。当 < 0.05 时，结果被认为具有统计学意义。
白皮樟的提取物在所有测试剂量（100、200 和 400mg/kg）下均显著降低总酸度（<0.001）。与载体（NC）相比，所有测试剂量的水-甲醇提取物均显著降低胃容积（<0.01）。胃 pH 值在 200 和 400mg/kg 时显著升高（<0.05）。同样，与 NC 相比，200mg/kg 和 400mg/kg 也显著降低了胃溃疡（<0.05）。在重复给予水-甲醇提取物和溶剂级分时，200mg/kg 的水-甲醇提取物和水级分显示出对溃疡指数的显著降低（<0.05）。在所有测试剂量的水-甲醇提取物中，对吲哚美辛诱导的溃疡的愈合作用不显著（>0.05）。
研究表明，白皮樟的茎皮具有潜在的抗溃疡活性，这可能是由于其具有抗分泌或细胞保护作用。
