促甲状腺激素释放激素类似物对巴氯芬引起的腹后基底核丘脑传递减少的拮抗作用。

Antagonism of baclofen induced reduction in ventrobasal thalamic transmission by a TRH analogue.

作者信息

Clarke K A, Djourhi L

机构信息

Department of Biomedical Science, University of Sheffield, UK.

出版信息

Neuropeptides. 1990 Sep;17(1):23-7. doi: 10.1016/0143-4179(90)90137-n.

DOI:10.1016/0143-4179(90)90137-n

PMID:2177166

Abstract

It has been shown previously that baclofen, the GABB beta receptor agonist, reduces the excitability of ventrobasal thalamic relay neurons measured by increases in latency and decreased discharge probability, while thyrotropin releasing hormone (TRH) analogues have the opposite effects. The present experiments have shown that the excitability reducing effects of baclofen on ventrobasal transmission are antagonised by the administration of TRH analogue CG3703. These results are discussed in the context of possible GABAergic and TRHergic modulation of VBT transmission from the thalamic reticular nucleus.

摘要

先前的研究表明，γ-氨基丁酸β受体激动剂巴氯芬可通过延长潜伏期和降低放电概率来降低腹侧基底丘脑中继神经元的兴奋性，而促甲状腺激素释放激素（TRH）类似物则具有相反的作用。目前的实验表明，给予TRH类似物CG3703可拮抗巴氯芬对腹侧基底丘脑传递的兴奋性降低作用。本文结合丘脑网状核可能存在的γ-氨基丁酸能和促甲状腺激素释放激素能对腹侧基底丘脑传递的调节作用对这些结果进行了讨论。