Clarke K A
Neuropeptides. 1986 Jan;7(1):31-9. doi: 10.1016/0143-4179(86)90077-6.
Extracellular microelectrode recordings have been made from single ventrobasal thalamic neurones in rats anaesthetised with urethane. Injection of the thyrotropin releasing hormone (TRH) analogue RX77368 (2mg/kg), produced increases in spontaneous activity and decreases in the latency of response to peripheral stimulation, together with increased production of later, rhythmic discharges. These changes were maximal between 30 and 60 minutes after injection. Decreases in latency and increases in amplitude were also observed in the evoked potential recorded from the somatosensory cortex. These results are discussed in relation to previously observed effects of TRH. Since this system is important in the planning and execution of motor acts it is suggested that modification of information flow through this system could have effects on the production of motor activity.
在使用乌拉坦麻醉的大鼠中，已从单个腹侧基底丘脑神经元进行了细胞外微电极记录。注射促甲状腺激素释放激素（TRH）类似物RX77368（2mg/kg）后，自发活动增加，对周围刺激的反应潜伏期缩短，同时后期节律性放电增加。这些变化在注射后30至60分钟之间最为明显。在体感皮层记录的诱发电位中也观察到潜伏期缩短和振幅增加。结合先前观察到的TRH效应讨论了这些结果。由于该系统在运动行为的规划和执行中很重要，因此有人提出，通过该系统的信息流改变可能会对运动活动的产生产生影响。
