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免疫功能正常宿主中由鼻疽诺卡菌引起的肺部奴卡菌病——一例罕见病例报告。

Pulmonary nocardiosis due to Nocardia otitidiscaviarum in an immunocompetent host- a rare case report.

机构信息

Department of Medicine, KMC, Manipal, Manipal University, India.

出版信息

Asian Pac J Trop Med. 2011 May;4(5):414-6. doi: 10.1016/S1995-7645(11)60116-8. Epub 2011 Jun 22.

Abstract

Nocardiosis is a localized or disseminated infection caused by soil-borne aerobic actinomycetes. Pulmonary nocardiosis is a rare infection mostly occurring in immunocompromised patients. We reported a case of 36 year old immunocompetent non-smoker female patient with no premorbid illness who presented with fever, cough with scanty sputum, hemoptysis, left sided chest pain and exertional dyspnea for two weeks. There was no past history of tuberculosis, diabetes mellitus or steroid therapy. Chest X-ray showed homogenous peripherally based opacity in the left upper zone. Bronchoscopy was done and brushing sent for culture, which showed colonies with features of Nocardia species after 48 hours. Further phenotypic characterization revealed it to be Nocardia otitidiscaviarum. Patient was treated with cotrimaxazole for six months after which complete recovery was evidenced symptomatically and radiologically. We report this case to emphasize the fact that among the Nocardia species, Nocardia otitidiscaviarum as causative agent of pulmonary disease is rarely reported even in immunocompromised individuals.

摘要

诺卡氏菌病是一种由土壤源性需氧放线菌引起的局部或播散性感染。肺部诺卡氏菌病是一种罕见的感染,主要发生在免疫功能低下的患者中。我们报告了一例 36 岁免疫功能正常的非吸烟者女性患者,无既往疾病史,无糖尿病或类固醇治疗史。患者因发热、咳嗽、咳痰、咯血、左侧胸痛和活动后呼吸困难两周就诊。胸部 X 线显示左上区均匀的外周性不透明影。支气管镜检查并进行刷检培养,48 小时后显示出具有诺卡氏菌属特征的菌落。进一步的表型特征表明它是耳炎诺卡氏菌。患者接受复方磺胺甲噁唑治疗六个月后,症状和影像学均完全恢复。我们报告这个病例是为了强调一个事实,即在诺卡氏菌属中,耳炎诺卡氏菌作为肺部疾病的病原体,即使在免疫功能低下的个体中,也很少被报道。

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