Nardone Raffaele, Golaszewski Stefan, Trinka Eugen, Tezzon Frediano, Zuccoli Giulio
Franz Tappeiner Hospital, Merano, Italy.
J Child Neurol. 2011 Dec;26(12):1590-2. doi: 10.1177/0883073811413130. Epub 2011 Jul 19.
We report a case of acute disseminated encephalomyelitis preceding measles virus infection. Brain magnetic resonance imaging revealed signal intensity abnormalities in the basal ganglia and cortex consistent with acute disseminated encephalomyelitis. Fever and the first Koplik spots appeared 8 and 10 days later, respectively. This case supports the hypothesis that the immune-mediated demyelinating process may occur before the symptomatic phase of a viral infection. Therefore, children without history of infectious disorders should also have acute disseminated encephalomyelitis included in the differential considerations.
我们报告了一例在麻疹病毒感染之前发生急性播散性脑脊髓炎的病例。脑磁共振成像显示基底神经节和皮质信号强度异常，符合急性播散性脑脊髓炎表现。发热和第一批科氏斑分别在8天和10天后出现。该病例支持免疫介导的脱髓鞘过程可能在病毒感染症状期之前发生这一假说。因此，无感染性疾病史的儿童在鉴别诊断时也应考虑急性播散性脑脊髓炎。
