慢性肉芽肿病患儿每日两次泊沙康唑给药算法。
A twice daily posaconazole dosing algorithm for children with chronic granulomatous disease.
机构信息
Departments of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
出版信息
Pediatr Infect Dis J. 2011 Sep;30(9):794-7. doi: 10.1097/INF.0b013e3182195808.
PMID:21772229
Abstract
Posaconazole (PSZ) may be an attractive alternative for antifungal prophylaxis in children with chronic granulomatous disease. Experience with PSZ in pediatric patients is limited, and no specific dose recommendations exist. A twice daily dosing algorithm based on allometric scaling (body-weight based) for PSZ results in adequate exposure and appears to be safe in children with chronic granulomatous disease.
摘要
泊沙康唑（PSZ）可能是慢性肉芽肿病儿童抗真菌预防的一种有吸引力的选择。在儿科患者中使用 PSZ 的经验有限，并且不存在特定的剂量建议。基于 PSZ 体表面积比例法（基于体重）的每日两次给药方案可达到充分的暴露，并且在患有慢性肉芽肿病的儿童中似乎是安全的。
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