NF-κB 靶基因调控的层次结构。
Hierarchies of NF-κB target-gene regulation.
机构信息
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA.
出版信息
Nat Immunol. 2011 Jul 19;12(8):689-94. doi: 10.1038/ni.2070.
Abstract
Members of the NF-κB family of transcription factors function as dominant regulators of inducible gene expression in almost all cell types in response to a broad range of stimuli, with particularly important roles in coordinating both innate and adaptive immunity. This review summarizes the present knowledge and recent progress toward elucidating the numerous regulatory layers that confer target-gene selectivity in response to an NF-κB-inducing stimulus.
摘要
NF-κB 转录因子家族的成员作为几乎所有细胞类型中诱导基因表达的主要调节剂，在应对广泛的刺激时发挥作用，在协调先天免疫和适应性免疫方面具有特别重要的作用。本文总结了目前对于阐明 NF-κB 诱导刺激下赋予靶基因选择性的众多调控层的认识和最新进展。
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