Institut für Molekulare Immunologie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Nat Immunol. 2011 Jun 19;12(8):709-14. doi: 10.1038/ni.2055.
Activation of NF-κB transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-κB signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-κB response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.
先天或适应性免疫系统受体激活 NF-κB 转录因子对于宿主防御至关重要。然而，在危险消除后，NF-κB 信号需要被严格下调以维持组织内稳态。本综述强调了影响 NF-κB 激活蛋白数量、定位或构象特性的关键负调控原则，以减弱 NF-κB 反应。这些机制对于预防炎症、自身免疫性疾病和肿瘤发生是必需的。
