Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, Parc Scientifique de Luminy, Case 906, 13288 Marseille, France.
Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651. doi: 10.1101/cshperspect.a001651. Epub 2009 Oct 7.
The nuclear factor NF-kappaB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-kappaB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules. In this article, we describe how genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway. NF-kappaB has long been considered the "holy grail" as a target for new anti-inflammatory drugs; however, these recent studies suggest this pathway may prove a difficult target in the treatment of chronic disease. In this article, we discuss the role of NF-kappaB in inflammation in light of these recent studies.
核因子 NF-κB 途径长期以来一直被认为是典型的促炎信号通路，这主要基于 NF-κB 在促炎基因（包括细胞因子、趋化因子和黏附分子）表达中的作用。在本文中，我们将描述小鼠中的遗传证据如何揭示了 NF-κB 在炎症中的复杂作用，这表明该途径既具有促炎作用，也具有抗炎作用。NF-κB 长期以来一直被视为新的抗炎药物的“圣杯”靶点；然而，这些最近的研究表明，该途径在治疗慢性疾病时可能是一个难以攻克的靶点。在本文中，我们将根据这些最近的研究讨论 NF-κB 在炎症中的作用。
