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葡萄膜黑色素瘤

Uveal melanoma.

作者信息

Papastefanou Vasilios P, Cohen Victoria M L

机构信息

Ocular Oncology Service, Moorfields Eye Hospital, London EC1V 2PD, UK.

出版信息

J Skin Cancer. 2011;2011:573974. doi: 10.1155/2011/573974. Epub 2011 Jun 30.

DOI:10.1155/2011/573974
PMID:21773036
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3135138/
Abstract

Uveal melanoma is the most common primary intraocular malignancy and the leading primary intraocular disease which can be fatal in adults. In this paper epidemiologic, pathogenetic, and clinical aspects of uveal melanoma are discussed. Despite the advance in local ocular treatments, there has been no change in patient survival for three decades. Development of metastases affects prognosis significantly. Current survival rates, factors predictive of metastatic potential and metastatic screening algorithms are discussed. Proposed and emerging treatments for uveal melanoma metastases are also overviewed. Current advances in genetics and cytogenetics have provided a significant insight in tumours with high metastatic potential and the molecular mechanisms that underlie their development. Biopsy of those lesions may prove to be important for prognostication and to allow further research into genetic mutations and potential new therapeutic targets in the future.

摘要

葡萄膜黑色素瘤是最常见的原发性眼内恶性肿瘤，也是可导致成人死亡的主要原发性眼内疾病。本文讨论了葡萄膜黑色素瘤的流行病学、发病机制和临床方面。尽管局部眼部治疗取得了进展，但三十年来患者生存率并无变化。转移的发生对预后有显著影响。本文讨论了当前的生存率、转移潜能的预测因素和转移筛查算法。还概述了针对葡萄膜黑色素瘤转移的已提出和新出现的治疗方法。遗传学和细胞遗传学的当前进展为具有高转移潜能的肿瘤及其发展背后的分子机制提供了重要见解。对这些病变进行活检可能对预后评估很重要，并有助于未来进一步研究基因突变和潜在的新治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/041e/3135138/4d8661aaf03a/JSC2011-573974.011.jpg
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