Trop M, Schiffrin E J, Carter E A
Department of Pediatrics, Shriners Burns Institute, Boston, Massachusetts.
Burns. 1990 Oct;16(5):343-6. doi: 10.1016/0305-4179(90)90006-i.
We have examined the role of neutrophils in the alterations observed in the intestines of rats subjected to 40 per cent surface area scald injury. Histologically, there was no evidence of neutrophilia in the intestinal tissue, and myeloperoxidase activity in mucosal scrapings was not elevated. The distribution of labelled human neutrophils injected into the burned rats showed no enhancement of uptake in the intestines, although there was increased uptake by the lung. The present data suggest that neutrophil migration may not play a role in the alterations in small intestinal function and morphology seen in burn trauma in the rat, but may be a factor in lung damage associated with thermal injury.
我们研究了中性粒细胞在遭受40%体表面积烫伤的大鼠肠道中所观察到的变化中的作用。组织学检查显示，肠道组织中没有中性粒细胞增多的迹象，黏膜刮片中的髓过氧化物酶活性也未升高。注入烧伤大鼠体内的标记人中性粒细胞的分布情况表明，肠道中的摄取没有增强，尽管肺部的摄取有所增加。目前的数据表明，中性粒细胞迁移可能在大鼠烧伤创伤中所见的小肠功能和形态改变中不起作用，但可能是与热损伤相关的肺损伤的一个因素。
