Carter E A, Udall J N, Kirkham S E, Walker W A
Department of Medicine, Harvard Medical School, Boston, MA.
J Burn Care Rehabil. 1986 Nov-Dec;7(6):469-74. doi: 10.1097/00004630-198611000-00004.
The effect of acute burn trauma, produced by scalding hot water, on rat small intestinal nutrient absorption and DNA synthesis has been examined. Burned rats showed decreased small-intestine mucosal weight and altered small-intestine transport of nutrients (calcium, glucose, or amino acid) in vitro. In addition, there was decreased 3H-thymidine incorporation into intestinal DNA in vivo and decreased intestinal thymidine kinase activity in vitro 18 hours after acute burn. These data suggest that after the severe stress produced by acute burn trauma, there is altered small-intestine nutrient absorption and DNA synthesis. These alterations may affect delivery of nutrients by the gut to the burn patient.
研究了烫伤热水造成的急性烧伤创伤对大鼠小肠营养物质吸收和DNA合成的影响。烧伤大鼠的小肠黏膜重量减轻，体外小肠对营养物质（钙、葡萄糖或氨基酸）的转运发生改变。此外，急性烧伤18小时后，体内3H-胸腺嘧啶核苷掺入肠道DNA减少，体外肠道胸苷激酶活性降低。这些数据表明，急性烧伤创伤产生的严重应激后，小肠营养物质吸收和DNA合成发生改变。这些改变可能会影响肠道向烧伤患者输送营养物质。
