三环半缩醛的 1,3-偶极环加成反应。通过无催化剂生成亚胺叶立德合成喹诺卡嗪核心。
1,3-dipolar cycloadditions from tricyclic hemiaminals. Synthesis of the quinocarcin core through catalyst-free generation of azomethine ylides.
机构信息
Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
出版信息
Org Biomol Chem. 2011 Sep 21;9(18):6271-7. doi: 10.1039/c1ob05181d. Epub 2011 Jul 19.
PMID:21773620
Abstract
The generation of azomethine ylides from the readily accessible hemiaminals 3 and 8 or from iminium salt 10 was studied. Compounds 8 gave anti- and syn-cycloadducts containing the quinocarcin core through a catalyst-free dehydration process.
摘要
研究了从易得的半胺 3 和 8 或亚胺盐 10 生成亚胺叶立德。化合物 8 通过无催化剂脱水过程生成了含有醌卡宾核的反式和顺式环加成产物。
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