嗯酮与亚胺叶立德的催化不对称 1,3-偶极环加成反应。
The catalytic asymmetric 1,3-dipolar cycloaddition of ynones with azomethine ylides.
机构信息
School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, 221116, China.
出版信息
Org Lett. 2011 Sep 2;13(17):4680-3. doi: 10.1021/ol201898x. Epub 2011 Aug 9.
PMID:21827140
Abstract
The first catalytic asymmetric 1,3-dipolar cycloaddition of electron-deficient carbon-carbon triple bonds with azomethine ylides has been established. This reaction provides an unprecedented approach to access novel 2,5-dihydropyrrole derivatives with potential bioactivities in perfect enantioselectivities of up to >99% ee.
摘要
首例缺电子碳-碳三键与亚胺叶立德的催化不对称 1,3-偶极环加成反应已经建立。该反应为获得具有潜在生物活性的新型 2,5-二氢吡咯衍生物提供了一种前所未有的方法，对映选择性高达 >99%ee。
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