使用烯烃氨基甲酰化反应合成并研究不对称亚胺的反应活性。

Synthesis and reactivity of unsymmetrical azomethine imines formed using alkene aminocarbonylation.

机构信息

Center for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5.

出版信息

Org Lett. 2013 Apr 19;15(8):1890-3. doi: 10.1021/ol400542b. Epub 2013 Apr 8.

DOI:10.1021/ol400542b

PMID:23565796

Abstract

Complex cyclic azomethine imines possessing a β-aminocarbonyl motif can be accessed readily from simple alkenes and hydrazones. This alkene aminocarbonylation approach allows formation of ketone-derived azomethine imines of unprecedented complexity. Since unsymmetrical hydrazones are used, two stereoisomers are formed: the reactivity of chiral derivatives is explored in both intra- and intermolecular systems.

摘要

具有β-氨甲酰基结构的复杂环状亚胺可以很容易地从简单的烯烃和腙中获得。这种烯烃氨甲酰化方法允许形成前所未有的复杂酮衍生亚胺亚胺。由于使用了不对称腙，因此形成了两种立体异构体：在分子内和分子间系统中都探索了手性衍生物的反应性。