Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
J Bone Miner Metab. 2012 Mar;30(2):183-92. doi: 10.1007/s00774-011-0300-x. Epub 2011 Jul 20.
We investigated the prevalence and risk factors of vertebral fractures in Korea. In a community-based prospective epidemiology study, 1,155 men and 1,529 women (mean age 59 years, range 43-74) were recruited from Ansung, a rural Korean community. Prevalent vertebral fractures were identified on the lateral spinal radiographs at T11 to L4 using vertebral morphometry. Bone mineral density (BMD) was measured at the lumbar spine, femur neck and total hip. Of the 2,684 subjects, 137 (11.9%) men and 227 (14.8%) women had vertebral fractures and the standardized prevalence for vertebral fractures using the age distribution of Korean population was 8.8% in men and 12.6% in women. In univariate analysis, older age, low hip circumference, low BMD, low income and education levels in both sexes, previous history of fracture in men, high waist-to-hip circumference ratio, postmenopausal status, longer duration since menopause, and higher number of pregnancies and deliveries in women were associated with an increased risk of vertebral fractures. However, after adjusting for age, only low BMD in both sexes and a previous history of fracture in men were significantly associated with an increased risk of vertebral fractures. Vertebral fractures are prevalent in Korea as in other countries. Older age, low BMD and a previous history of fracture are significant risk factors for vertebral fractures.
我们调查了韩国的椎体骨折患病率和危险因素。在一项基于社区的前瞻性流行病学研究中，我们从韩国农村社区安城招募了 1155 名男性和 1529 名女性（平均年龄 59 岁，范围 43-74 岁）。使用椎体形态计量学，在 T11 到 L4 的侧位脊柱 X 光片上确定现患椎体骨折。在腰椎、股骨颈和全髋关节测量骨密度（BMD）。在 2684 名受试者中，137 名（11.9%）男性和 227 名（14.8%）女性有椎体骨折，使用韩国人口年龄分布的标准化患病率，男性为 8.8%，女性为 12.6%。单因素分析显示，年龄较大、髋围较小、BMD 较低、收入和教育水平较低、男性有骨折史、腰臀比高、绝经后状态、绝经后时间较长、女性妊娠和分娩次数较多，与椎体骨折风险增加相关。然而，在调整年龄后，只有男性和女性的低 BMD 以及男性的骨折史与椎体骨折风险增加显著相关。椎体骨折在韩国和其他国家一样普遍。年龄较大、BMD 较低和骨折史是椎体骨折的重要危险因素。
