Department of Internal Medicine, Chonnam National University College of Medicine, Gwangju, Korea.
J Bone Miner Metab. 2013 Mar;31(2):161-8. doi: 10.1007/s00774-012-0398-5. Epub 2012 Oct 18.
Although type 2 diabetes mellitus (T2DM) has been associated with an increase in fracture risk, there is no data regarding the prevalence of vertebral fractures or its risk factors for patients with T2DM in Korea. In this cross-sectional study, we recruited postmenopausal women with T2DM from 24 tertiary hospital diabetes clinics in Korea. Prevalent vertebral fractures were identified on lateral spinal radiographs of thoracolumbar vertebrae by vertebral morphometry. Demographic and biochemical characteristics related to diabetes were obtained, and bone mineral density of the lumbar spine and femoral neck, which was available in 752 (33.6 %) and 675 (30.1 %) patients, respectively, was also analyzed. Of the 2239 subjects recruited (mean age 63.9 years), a total of 970 (43.3 %) subjects had vertebral fractures. In the bivariate analysis, history of fragility fractures after 50 years of age, microalbuminuria, presence of cardiovascular disease (myocardial infarction, angina, cerebrovascular complications of cardiovascular disease), and presence of osteoporosis at the total hip were significantly associated with the presence of vertebral fractures, after adjusting for age. In the multivariate analysis, the presence of cardiovascular diseases in addition to advancing age and history of fragility fractures was significantly associated with increased odds of vertebral fractures. Vertebral fractures were highly prevalent in postmenopausal women with T2DM in this study conducted in Korea, and the presence of cardiovascular disease, in addition to older age and history of fragility fractures, was significantly associated with the presence of vertebral fractures.
尽管 2 型糖尿病（T2DM）与骨折风险增加有关，但韩国尚无关于 T2DM 患者椎体骨折的患病率及其危险因素的数据。在这项横断面研究中，我们从韩国 24 家三级医院的糖尿病诊所招募了绝经后 T2DM 女性。通过椎体形态计量学在胸腰椎侧位脊柱 X 光片上确定现患椎体骨折。获得与糖尿病相关的人口统计学和生化特征，并且分析了腰椎和股骨颈的骨密度，分别有 752（33.6%）和 675（30.1%）名患者可用。在招募的 2239 名受试者中（平均年龄 63.9 岁），共有 970 名（43.3%）受试者有椎体骨折。在单变量分析中，50 岁以后脆性骨折史、微量白蛋白尿、心血管疾病（心肌梗塞、心绞痛、心血管疾病的脑血管并发症）和全髋关节骨质疏松症的存在与椎体骨折的存在显著相关，调整年龄后。在多变量分析中，除了年龄增长和脆性骨折史外，存在心血管疾病与椎体骨折的几率增加显著相关。在这项在韩国进行的研究中，绝经后 T2DM 女性的椎体骨折患病率很高，除了年龄较大和脆性骨折史外，存在心血管疾病与椎体骨折的存在显著相关。
