Zhang Z, Tu Z, Zhu Z
Department of physiology, Faculty of Bsic Medical Sciences, Tongji Medical University, Wuhan.
Zhen Ci Yan Jiu. 1990;15(2):112-6.
Experiments were performed on 42 female albino rats weighing from 180-250 gm. The pain threshold (PT) was determined by radiant heat induced tail-flick method. The cAMP contents in various regions of brain were measured by radio-immunoassay. Electro-acupuncture (EA) at bilateral "Zusanli" and "Sanyinjian" in rats significantly elevated PT, increased the content of cAMP in the hypophysis, while decreased that of septal nucleus. No effects were found in the basal PT and the cAMP contents of the hypophysis and septal nuclei after intraventricular injection of TRH. After TRH administered intraventricularly, however, EA didn't elevate PT, but still increased hypophysial cAMP with a decrease in the level of cAMP in the septal nucleus. These results suggest that the cAMP may be related to analgesic effect induced by EA in some brain regions, and TRH injected into cerebral ventricles can antagonize the analgesic effect caused by EA, but this effect seemed to have nn relation to the contents to the contents of cAMP of hypophysis, septal nucleus, caudatum, hypothalamus and thalamus.
对42只体重在180 - 250克之间的雌性白化病大鼠进行了实验。通过辐射热诱导甩尾法测定痛阈（PT）。采用放射免疫分析法测量大脑各区域的环磷酸腺苷（cAMP）含量。对大鼠双侧“足三里”和“三阴交”进行电针（EA），可显著提高痛阈，增加垂体中cAMP的含量，同时降低隔核中的cAMP含量。脑室内注射促甲状腺激素释放激素（TRH）后，基础痛阈以及垂体和隔核中的cAMP含量均未发现变化。然而，脑室内注射TRH后，电针虽未提高痛阈，但仍可增加垂体cAMP含量，同时降低隔核中cAMP水平。这些结果表明，cAMP可能在某些脑区与电针诱导的镇痛作用有关，向脑室注射TRH可拮抗电针引起的镇痛作用，但这种作用似乎与垂体、隔核、尾状核、下丘脑和丘脑的cAMP含量无关。
