[The influence of acupuncture at zusanli on cyclic nucleotide contents of plasma, different brain regions and spleen in rats].

We observed cyclic nucleotide content of plasma, brain and Spleen tissues when analgesia was produced by acupuncture at the Zusanli. The restrained group without acupuncture was as blank control and acupuncture at Taichong as acupuncture control. We found that after acupuncture at Zusanli the concentration of cyclic nucleotide in plasma was increased significantly (P < 0.05) and the cAMP concentration of spleen had a tendency of enhancement, but the content of cAMP in the cortex had a tendency of decrease. The concentration of cAMP, cGMP and its ratio cAMP/cGMP was different in cortex and spinal cord between acupuncture at Zusanli and Taichong groups. These results showed that acupuncture at Zusanli and Taichong could induce different changes of concentration of cAMP and cGMP.