Neurology, Internal Medicine, Sakura Medical Center, Toho University, 564-1 Shimoshizu, Sakura 285-8741, Japan.
Neurol Sci. 2012 Apr;33(2):347-50. doi: 10.1007/s10072-011-0710-5. Epub 2011 Jul 20.
A 69-year-old, chronically constipated patient with Parkinson's disease developed fecal impaction and the malignant syndrome simultaneously, even while the patient was taking anti-parkinsonian drugs as prescribed. Administration of intravenous levodopa and oral Dai-kenchu-tou, an herbal medicine with serotonergic 5-HT3 receptor agonistic property successfully ameliorated his clinical symptoms. Constipation may trigger worsening of Parkinson's disease and occurrence of the malignant syndrome by affecting levodopa absorption. Further, improved bowel motility may prevent worsening of Parkinson's disease and occurrence of the malignant syndrome.
一位 69 岁的慢性便秘帕金森病患者同时发生了粪嵌塞和恶性综合征，尽管患者正在按规定服用抗帕金森病药物。静脉注射左旋多巴和口服大建中汤（一种具有血清素 5-HT3 受体激动作用的草药）成功改善了他的临床症状。便秘可能通过影响左旋多巴的吸收而加重帕金森病并引发恶性综合征。此外，改善肠道蠕动可能预防帕金森病恶化和恶性综合征的发生。
