Department of Food Technology, Nutrition and Food Science, Veterinary Faculty, University of Murcia, Regional Campus of International Excellence "Campus Mare Nostrum", Campus de Espinardo, Espinardo, 30100 Murcia, Spain.
Carrera Nutrición y Dietética, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Providencia 7500975, Chile.
Nutrients. 2024 Sep 13;16(18):3092. doi: 10.3390/nu16183092.
Parkinson's disease (PD) is a highly prevalent disease characterized by motor and non-motor symptoms; the latter include constipation, which is considered a prodromal symptom. On the other hand, sarcopenia, polypharmacy, and malnutrition due to deficits are common in PD and lead to poorer health and quality of life.
to associate constipation and use of levodopa with nutritional status, sarcopenia, duration and stage of the disease, and polypharmacy in individuals with PD.
analytical cross-sectional observational study where an online survey was applied to 161 people suffering from PD.
a significant association is observed between constipation and BMI ( = 0.022), as well as between the use of levodopa with BMI ( = 0.049) and polypharmacy ( = 0.046). On the other hand, there is a relationship between the average time of PD diagnosis and constipation ( = 0.0047). Finally, there is a relationship between SARC-F score applied to those over 60 years of age ( = 0.0446) and the use of levodopa. Having sarcopenia, being overweight, and having had the disease for less than five years is associated with a higher probability of experiencing constipation, according to the logistic regression analysis ( > 0.005).
nutritional assessment and subsequent follow-up is of vital importance to avoid complications that could be associated with levodopa use, constipation, and sarcopenia.
帕金森病（PD）是一种高发疾病，其特征为运动和非运动症状；后者包括便秘，被认为是前驱症状。另一方面，在 PD 患者中，肌少症、药物滥用和因缺陷导致的营养不良很常见，这会导致健康状况和生活质量下降。
将便秘和左旋多巴的使用与营养状况、肌少症、疾病持续时间和阶段以及 PD 患者的药物滥用联系起来。
这是一项分析性横断面观察研究，对 161 名患有 PD 的患者进行了在线调查。
观察到便秘与 BMI（ = 0.022）之间存在显著关联，左旋多巴的使用与 BMI（ = 0.049）和药物滥用（ = 0.046）之间也存在关联。另一方面，PD 诊断的平均时间与便秘之间存在关系（ = 0.0047）。最后，在 60 岁以上人群中应用 SARC-F 评分与左旋多巴的使用之间存在关系（ = 0.0446）。根据逻辑回归分析，肌少症、超重和患病不到五年与更高的便秘发生概率相关（ > 0.005）。
营养评估和随后的随访对于避免可能与左旋多巴使用、便秘和肌少症相关的并发症至关重要。
