微小 RNA 与癌症治疗。
MicroRNAs and cancer therapeutics.
机构信息
State Key Laboratory of Emerging Infectious Diseases, Research Centre of Infection and Immunology, Department of Microbiology Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China.
出版信息
Pharm Res. 2011 Dec;28(12):3043-9. doi: 10.1007/s11095-011-0526-2. Epub 2011 Jul 20.
Abstract
MicroRNAs (miRNAs) are small physiological non-coding RNAs that regulate gene expression through an RNA interference (RNAi) mechanism. The expression of miRNAs is tightly controlled both spatially and temporally. Aberrant miRNA expression has been correlated with various cancers. Recent findings suggest that some miRNAs can function as tumor suppressors or oncogenes. In model experiments, the cancer phenotype of some cells can be reverted to normal when the cells are treated with miRNA mimics or inhibitors. Here, we discuss in brief the potential utility of miRNA-based cancer therapy as well as the current limitations thwarting their useful clinical application.
摘要
MicroRNAs (miRNAs) 是小的生理非编码 RNA，通过 RNA 干扰 (RNAi) 机制调节基因表达。miRNAs 的表达在空间和时间上受到严格控制。miRNA 的异常表达与各种癌症有关。最近的研究结果表明，一些 miRNA 可以作为肿瘤抑制因子或癌基因发挥作用。在模型实验中，当用 miRNA 模拟物或抑制剂处理细胞时，一些细胞的癌症表型可以恢复正常。在这里，我们简要讨论了基于 miRNA 的癌症治疗的潜在应用，以及阻碍其临床应用的当前限制。
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