Hamang Anniken, Eide Geir Egil, Rokne Berit, Nordin Karin, Bjorvatn Cathrine, Øyen Nina
Genetic Epidemiology Research Group, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway.
J Genet Couns. 2012 Feb;21(1):72-84. doi: 10.1007/s10897-011-9393-6. Epub 2011 Jul 20.
Since Long QT syndrome and Hypertrophic cardiomyopathy are inherited cardiac disorders that may cause syncope, palpitations, serious arrhythmias, and sudden cardiac death, at-risk individuals may experience heart-focused anxiety. In a prospective multi-site study, 126 Norwegian patients attending genetic counseling were followed 1 year with multiple administration of questionnaires, including the Cardiac Anxiety Questionnaire, measuring three distinct symptoms of heart-focused anxiety- avoidance, attention, and fear-in mixed linear analyses. Overall, at 1-year follow-up, patients with clinical diagnosis as compared to patients at genetic risk had significantly higher scores of avoidance (p < .002), attention (p < .005), and fear (p < .007). Sudden cardiac death in close relatives, uncertainty whether other relatives previously had undergone genetic testing, patients' perceived general health, self-efficacy expectations and procedural satisfaction with genetic counseling were influential in predicting the different symptoms of heart-focused anxiety over time.
由于长QT综合征和肥厚型心肌病是遗传性心脏疾病，可能导致晕厥、心悸、严重心律失常和心源性猝死，高危个体可能会出现专注于心脏的焦虑。在一项前瞻性多中心研究中，对126名接受遗传咨询的挪威患者进行了为期1年的随访，多次发放问卷，包括心脏焦虑问卷，在混合线性分析中测量专注于心脏焦虑的三种不同症状——回避、注意力和恐惧。总体而言，在1年随访时，临床诊断患者与遗传风险患者相比，回避（p < 0.002）、注意力（p < 0.005）和恐惧（p < 0.007）得分显著更高。近亲的心源性猝死、其他亲属之前是否接受过基因检测的不确定性、患者感知的总体健康状况、自我效能期望以及对遗传咨询的程序满意度，对预测随时间变化的专注于心脏焦虑的不同症状有影响。
