Department of General Surgery, Kumamoto Rousai Hospital, Kumamoto, Japan.
Surg Today. 2011 Aug;41(8):1145-9. doi: 10.1007/s00595-010-4406-x. Epub 2011 Jul 20.
A 29-year-old woman presented with a painful right breast tumor, measuring 15 cm in diameter, which had progressed rapidly over 3 months. Core needle biopsy of the tumor revealed a malignant mesenchymal tumor. A mastectomy was performed, and pathological examination of the tumor showed stromal sarcoma. Solitary pleural dissemination in the right lung was suspected, based on the computed tomography image taken before the operation. Two months after surgery, bilateral multiple lung nodules were demonstrated. Systemic chemotherapy with doxorubicin plus ifosfamide was performed, and 3 months later the lung metastases had disappeared. Moreover, there is still no sign of recurrence at 5 months after the initiation of the chemotherapy. Breast stromal sarcoma is very rare, accounting for less than 1% of mammary neoplasms, and the treatment strategy is not well established, especially regarding chemotherapy. This case demonstrates the effectiveness of chemotherapy with doxorubicin plus ifosfamide for lung metastases from breast stromal sarcoma.
一位 29 岁女性因右乳房肿瘤出现疼痛就诊，肿瘤直径 15cm，在 3 个月内迅速增大。肿瘤的粗针穿刺活检显示为恶性间叶性肿瘤。行乳房切除术，肿瘤的病理检查显示为梭形细胞肉瘤。术前的 CT 图像提示右肺孤立性胸膜播散。术后 2 个月，显示双侧多发肺结节。行多柔比星联合异环磷酰胺的全身化疗，3 个月后肺部转移灶消失。化疗开始后 5 个月，仍未见复发迹象。乳腺间质肉瘤非常罕见，占乳腺肿瘤的比例不到 1%，其治疗策略尚未明确，特别是化疗方面。本病例表明多柔比星联合异环磷酰胺化疗对乳腺间质肉瘤肺转移的有效性。
