Otto G, Heuschen U, Hofmann W, Schlag P, Herfarth C
Chirurgische Universitätsklinik Heidelberg.
Chirurg. 1990 Oct;61(10):705-10.
Prognostically relevant factors and treatment were analysed in 103 patients suffering from primary epithelial liver tumors (88 HCC, 15 CCC). Ninety of them underwent operations: 14 liver transplantations, 32 resections, 44 explorative laparotomies. The resection rate was 38%, the 30-day mortality in transplantation 14%, in resection 22%. The 5-year survival after resection was about 25%. Liver transplantation resulted in 50% 1-year and 40% 2-year survival. Long-term prognosis was positively influenced by cirrhosis and formation of a tumor capsule. Indications for operative management depend only on extension of tumor growth and concomiting liver cirrhosis as biology of epithelial liver tumors is poorly understood.
对103例原发性上皮性肝肿瘤患者(88例肝细胞癌,15例胆管细胞癌)的预后相关因素及治疗情况进行了分析。其中90例接受了手术:14例肝移植,32例切除术,44例剖腹探查术。切除率为38%,移植术后30天死亡率为14%,切除术后为22%。切除术后5年生存率约为25%。肝移植术后1年生存率为50%,2年生存率为40%。肝硬化和肿瘤包膜形成对长期预后有积极影响。由于对上皮性肝肿瘤的生物学特性了解甚少,手术治疗的指征仅取决于肿瘤生长的范围和并存的肝硬化情况。