Inoue Daisuke
Third Department of Medicine, Teikyo University Chiba Medical Center.
Nihon Rinsho. 2011 Jul;69(7):1295-9.
Involutional osteoporosis is one of the most prevalent diseases all over the world. Some osteoporotic patients, however, suffer from a co-existent disease that causes or accelerates development of osteoporosis. In contrast to primary osteoporosis, such "secondary" osteoporosis is more common in men. Recent studies have, revealed that more and more diseases and drugs increase fragility fractures. Such a comorbidity is often a weak risk factor by itself rather than "a cause" of osteoporosis, but sometimes multiple risk factors are found in a single patient. It is therefore important for physicians to evaluate and integrate such risk factors for clinical decisions. In this review, I will summarize secondary causes of osteoporosis and discuss a pathophysiological link between cardiovascular disease and osteoporosis as an example.
退行性骨质疏松症是全球最常见的疾病之一。然而，一些骨质疏松症患者同时患有导致或加速骨质疏松症发展的疾病。与原发性骨质疏松症不同，这种“继发性”骨质疏松症在男性中更为常见。最近的研究表明，越来越多的疾病和药物会增加脆性骨折的风险。这种合并症本身往往是一个较弱的风险因素，而非骨质疏松症的“病因”，但有时在单个患者中会发现多种风险因素。因此，医生评估和综合这些风险因素以做出临床决策非常重要。在本综述中，我将总结骨质疏松症的继发性病因，并以心血管疾病与骨质疏松症之间的病理生理联系为例进行讨论。
