Samofalova D A, Karpov P A, Nyporko A Iu, Blium Ia B
Tsitol Genet. 2011 May-Jun;45(3):26-34.
The homology modeling, based on known temple structures of Homo sapiens protein phosphatase type-1 and -2A was implemented. The spatial structures of the human protein phosphatases and their plant homologs from Arabidopsis thaliana was predicted. The quality of models was confirmed by conformational analysis and root mean square deviations. The sites of okadaic acid binding in molecules of plant protein phosphatases (type-1 and -2A) were proved by the data of comparative analysis and molecular dynamics.
基于已知的人类1型和2A型蛋白磷酸酶的晶体结构进行同源建模。预测了人类蛋白磷酸酶及其来自拟南芥的植物同源物的空间结构。通过构象分析和均方根偏差确认了模型的质量。通过比较分析和分子动力学数据证明了植物蛋白磷酸酶（1型和2A型）分子中冈田酸的结合位点。
