原甲藻属海洋甲藻中的聚酮化合物，其 okadaic 酸类似物的生物合成来源和生物活性。

Polyketides from marine dinoflagellates of the genus Prorocentrum, biosynthetic origin and bioactivity of their okadaic acid analogues.

机构信息

Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, China.

出版信息

Mini Rev Med Chem. 2010 Jan;10(1):51-61. doi: 10.2174/138955710791112541.

DOI:10.2174/138955710791112541

PMID:20105116

Abstract

Marine dinoflagellates of the genus Prorocentrum are famous for the production of okadaic acid (OA) and its analogues. This review covers first the source, chemistry and bioactivity of polyketides from Prorocentrum species. Then recent advances in the studies of biosynthetic origin of OA and its analogues are included. Moreover, the pharmacophore for the selective inhibition of OA to protein phosphatases types 1 (PP1) and 2A (PP2A) is highlighted.

摘要

海洋甲藻属中的原甲藻属以产生 okadaic 酸（OA）及其类似物而闻名。这篇综述首先涵盖了原甲藻属物种的聚酮化合物的来源、化学结构和生物活性。然后介绍了 OA 及其类似物生物合成起源研究的最新进展。此外，还强调了 OA 对蛋白磷酸酶 1（PP1）和 2A（PP2A）选择性抑制的药效团。