Centre for Medicinal Food & Applied Nutrition, Department of Food Technology & Biochemical Engineering, Jadavpur University, Kolkata-700032, India.
Curr Pharm Des. 2011;17(21):2196-205. doi: 10.2174/138161211796957472.
Vitamin E family constitutes of tocopherol and tocotrienol. Each form has several isomers: alpha,beta, gamma, delta, desmo and didesmo. Although tocopherol is known much earlier, tocotrienol has been discovered more recently.Tocotrienol has higher antioxidant potential than tocopherol. Research shows that tocotrienol can inhibit the induced oxidative damage to lipids and proteins. Cholesterol biosynthesis pathway requires HMG Co A reductase. Tocotrienol degrades HMG Co A reductase protein and in turn lowers cholesterol synthesis. Tocotrienol can reverse ischemia-reperfusion which mediates cardiac dysfunction and induces c-Src protein expression. Tocotrienol prevents oxytosis and offers protection against Alzheimer's disease, Parkinson's disease, Hungtington's disease. Tocotrienol exerts anticancer property through cell cycle arrest, induction of apoptosis, inhibition of angiogenesis; antitumor activity. Tocotrienol also possesses anti-inflammatory, antidiabetic, antiadipogenic and antiatherogenic effect.
维生素 E 家族包括生育酚和三烯生育酚。每种形式都有几个异构体：α、β、γ、δ、去甲和二去甲。虽然生育酚被人们更早地了解，但三烯生育酚是最近才被发现的。三烯生育酚的抗氧化能力比生育酚高。研究表明，三烯生育酚可以抑制脂质和蛋白质的诱导氧化损伤。胆固醇生物合成途径需要 HMG Co A 还原酶。三烯生育酚降解 HMG Co A 还原酶蛋白，从而降低胆固醇合成。三烯生育酚可以逆转缺血再灌注，介导心脏功能障碍并诱导 c-Src 蛋白表达。三烯生育酚可以防止细胞凋亡，并预防阿尔茨海默病、帕金森病、亨廷顿病。三烯生育酚通过细胞周期停滞、诱导细胞凋亡、抑制血管生成发挥抗癌作用；具有抗肿瘤活性。三烯生育酚还具有抗炎、抗糖尿病、抗脂肪生成和抗动脉粥样硬化作用。
