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听觉和前庭毛细胞静纤毛:功能与内耳疾病之间的关系

Auditory and vestibular hair cell stereocilia: relationship between functionality and inner ear disease.

作者信息

Ciuman R R

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, Marienhospital Gelsenkirchen, Germany.

出版信息

J Laryngol Otol. 2011 Oct;125(10):991-1003. doi: 10.1017/S0022215111001459. Epub 2011 Jul 21.

DOI:10.1017/S0022215111001459
PMID:21774850
Abstract

The stereocilia of the inner ear are unique cellular structures which correlate anatomically with distinct cochlear functions, including mechanoelectrical transduction, cochlear amplification, adaptation, frequency selectivity and tuning. Their function is impaired by inner ear stressors, by various types of hereditary deafness, syndromic hearing loss and inner ear disease (e.g. Ménière's disease). The anatomical and physiological characteristics of stereocilia are discussed in relation to inner ear malfunctions.

摘要

内耳的静纤毛是独特的细胞结构,在解剖学上与不同的耳蜗功能相关,包括机械电转换、耳蜗放大、适应性、频率选择性和调谐。它们的功能会因内耳应激源、各种类型的遗传性耳聋、综合征性听力损失和内耳疾病(如梅尼埃病)而受损。本文将讨论静纤毛的解剖学和生理学特征与内耳功能障碍的关系。

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