Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
Scand J Public Health. 2011 Jul;39(7 Suppl):136-40. doi: 10.1177/1403494811399166.
Based on evidence from animal experiments and case reports, certain occupational exposures may contribute to yet undetected cancer risk in humans. Since traditional epidemiological studies are time consuming, the use of existing information from registers may facilitate the research process. Due to the existence of a unique personal identification number (CPR-number), a national cancer register operating since 1943, a nationwide pension fund scheme with compulsory membership for all employees covering long-term individual employment history, and sometimes with addition of information from external sources, e.g. interviews or job exposure matrices, it is possible to conduct large nationwide studies of occupational exposures and cancer risk in Denmark.
In this review we give three examples of cancer studies of widespread occupational exposures: formaldehyde, night shift work, and bitumen.
Results from register-based studies have contributed to the now-existing evidence on occupational exposures and risk of cancer.
基于动物实验和病例报告的证据,某些职业暴露可能会导致人类尚未发现的癌症风险。由于传统的流行病学研究耗时较长,因此利用现有登记处的信息可能会促进研究过程。由于丹麦自 1943 年以来一直设有一个全国性的癌症登记处,该登记处使用独特的个人身份号码(CPR 号码),还有一个为所有员工提供长期个人就业历史的强制性全国性养老金计划,有时还会从外部来源(例如访谈或职业暴露矩阵)添加信息,因此可以在丹麦进行广泛的职业暴露和癌症风险的全国性研究。
在本综述中,我们举了三个关于广泛职业暴露的癌症研究的例子:甲醛、夜班工作和沥青。
基于登记处的研究结果为现有的职业暴露与癌症风险的证据做出了贡献。