Elkins D B, Haswell-Elkins M R, Mairiang E, Mairiang P, Sithithaworn P, Kaewkes S, Bhudhisawasdi V, Uttaravichien T
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Thailand.
Trans R Soc Trop Med Hyg. 1990 Sep-Oct;84(5):715-9. doi: 10.1016/0035-9203(90)90159-c.
A group of 87 adults from a small village in north-east Thailand was chosen to undergo ultrasound investigation based on their intensity of infection with the liver fluke, Opisthorchis viverrini, or clinical status (history of jaundice, current hepatomegaly). From this group, 8 cases of suspected early cholangiocarcinoma were found, and the diagnostic features of 6 of the 8 were confirmed by computerized tomography scan and endoscopic retrograde cholangiopancreatography. In addition, several cases of mild gall-bladder disease, chronic cholecystitis, cholelithiasis and parenchymal liver disease were detected. A highly significant positive relationship between the intensity of liver fluke worm burden and the severity of biliary tract disease within individuals is reported. These results indicate that Opisthorchis is associated with moderate to severe hepatobiliary disease in a considerable proportion of infected individuals.
从泰国东北部一个小村庄选取了87名成年人，根据他们感染肝吸虫（华支睾吸虫）的程度或临床状况（黄疸病史、当前肝肿大）接受超声检查。在这个群体中，发现了8例疑似早期胆管癌的病例，其中6例的诊断特征通过计算机断层扫描和内镜逆行胰胆管造影得到证实。此外，还检测到几例轻度胆囊疾病、慢性胆囊炎、胆结石和实质性肝病。据报道，个体肝吸虫虫负荷强度与胆道疾病严重程度之间存在高度显著的正相关关系。这些结果表明，在相当比例的受感染个体中，华支睾吸虫与中度至重度肝胆疾病有关。
